I have been wishing someone would come up with a science.memeorandum for some time and now there is one: Postgenomic. The site created by Stew (still in beta) aims to aggregate discussions going on in the life science blogs about papers, conferences and general science news. This adds a needed feedback to the science blogosphere and therefore will, in my opinion, increase the quality of discussion.
This site can for example become an excellent repository for comments on papers. Instead of adding a comment on a paper in the journal website now you can just blog about it and the content gets aggregated on postgenomic. I am not sure but I think we could make a greasemonkey script to check the current web page for a DOI and see if there are reviews about it in postgenomic and add a little link somewhere.
Some more links about it:
Notes and more Notes