Thursday, June 03, 2004

Gene regulation: A reason for reading nonsense

The process of transcribing DNA can itself regulate gene expression in yeast: in the case concerned it is the very act of reading the DNA, not the message produced, that carries out the regulatory job.

A simple example where the RNA polymerase disrupts the expression of a gene by production of a upstream non-coding sequence. The message is not important only the actual reading trough the downstream promoter.